2-Bromoanisole → HCID 68576820, compound

HRID 1949014Notes

Reaction equation

Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[CH:6]=[CH:5]2.[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][NH2:18].[CH:23]([Sn](CCCC)(CCCC)CCCC)=[CH2:24].Br[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=1[O:45][CH3:46]>>[CH3:13][O:14][C:15]1[CH:22]=[CH:21][CH:20]=[CH:19][C:16]=1[CH2:17][NH:18][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([CH2:23][CH2:24][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][C:40]=3[O:45][CH3:46])[CH:3]=2)[N:8]=1

Participants

Reactant 4

HCID 113582-Bromoanisole

HCID 812922-Methoxybenzylamine

HCID 81998Tributylvinyltin

HCID 128940866-Bromo-2-chloroquinoline

Product 1

HCID 68576820HCID 68576820, compound

Procedure

The title compound, MS: m/e=399.3 (M+H+), was prepared in accordance with the general method of example 14 and 3 from 6-bromo-2-chloroquinoline, 2-methoxybenzylamine, vinyltributyltin and 2-bromoanisole.

Sources & evidence

ORD record: ord-a2fde248a2f74762a57041ccf782f281
Source dataset: uspto-grants-2013_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08399674B2

Reaction notes

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