Methylamine → HCID 67153434, compound

HRID 1949312Notes

Reaction equation

HRID 1949312 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=3)[N:18]=[C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])[CH:16]=2)[CH:10]=1)(=O)=O.CN.[CH:37]([OH:39])=[O:38].ClC1C=[C:43]([N:47]2C(C3C=CC=C(OCCCN(C)C)C=3)=CC(C(N3CC(=O)NC3)=O)=N2)C=CC=1>O1CCCC1>[CH:37]([OH:39])=[O:38].[Cl:26][C:22]1[CH:21]=[C:20]([N:19]2[C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:7][CH2:6][NH:47][CH3:43])[CH:10]=3)=[CH:16][C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])=[N:18]2)[CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 6329MethylamineHCID 58277451HCID 58277451, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 67153434HCID 67153434, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 121A and methylamine without the addition of tetrahydrofuran in analogy to the synthesis of the compound of Example 29. 26 mg (26% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-93eda6b2be954eb796dbe02b47f1bfd1
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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