1-Methylpiperazine → HCID 131730349, compound

HRID 1949314Notes

Reaction equation

HRID 1949314 reaction equation
CS(O[CH2:6][CH2:7][O:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([C:15]2[N:19]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[CH:21]=3)[N:18]=[C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])[CH:16]=2)[CH:10]=1)(=O)=O.[CH3:35][N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.[CH:42]([OH:44])=[O:43].ClC1C=C(N2C(C3C=CC=C(OCCCN(C)C)C=3)=CC(C(N3CC(=O)NC3)=O)=N2)C=CC=1>O1CCCC1>[CH:42]([OH:44])=[O:43].[CH:42]([OH:44])=[O:43].[Cl:26][C:22]1[CH:21]=[C:20]([N:19]2[C:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([O:8][CH2:7][CH2:6][N:39]4[CH2:40][CH2:41][N:36]([CH3:35])[CH2:37][CH2:38]4)[CH:10]=3)=[CH:16][C:17]([C:27]([N:29]3[CH2:33][C:32](=[O:34])[NH:31][CH2:30]3)=[O:28])=[N:18]2)[CH:25]=[CH:24][CH:23]=1

Participants

5

Reactant 3

HCID 531671-MethylpiperazineHCID 58277451HCID 58277451, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 131730349HCID 131730349, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 121A and 1-methylpiperazine without the addition of tetrahydrofuran in analogy to the synthesis of the compound of Example 29. 46 mg (38% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-8c3d68a749e1405f896b18ffa2b17a75
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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