Pyrrolidine → HCID 58277440, compound

HRID 1949324Notes

Reaction equation

HRID 1949324 reaction equation
Cl[CH2:2][CH2:3][O:4][C:5]1[CH:6]=[C:7]([C:12]2[N:16]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[C:19]([Cl:24])[CH:18]=3)[N:15]=[C:14]([C:25]([N:27]3[CH2:31][C:30](=[O:32])[NH:29][CH2:28]3)=[O:26])[CH:13]=2)[CH:8]=[C:9]([F:11])[CH:10]=1.[NH:33]1[CH2:37][CH2:36][CH2:35][CH2:34]1.C(O)=O.ClC1C=C(N2C(C3C=CC=C(OCCCN(C)C)C=3)=CC(C(N3CC(=O)NC3)=O)=N2)C=CC=1>C(O)=O>[Cl:24][C:19]1[CH:18]=[C:17]([N:16]2[C:12]([C:7]3[CH:6]=[C:5]([O:4][CH2:3][CH2:2][N:33]4[CH2:37][CH2:36][CH2:35][CH2:34]4)[CH:10]=[C:9]([F:11])[CH:8]=3)=[CH:13][C:14]([C:25]([N:27]3[CH2:31][C:30](=[O:32])[NH:29][CH2:28]3)=[O:26])=[N:15]2)[CH:22]=[CH:21][C:20]=1[F:23]

Participants

5

Reactant 3

HCID 31268PyrrolidineHCID 58277419HCID 58277419, compoundHCID 67153505HCID 67153505, compound

Product 1

HCID 58277440HCID 58277440, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 119A and pyrrolidine without the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 29. 2.5 mg (5% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-7149d74b6aa341a7beabdc3dc2f94ba0
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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