Diisopropylethylamine → HCID 44230248, compound

HRID 1949327Notes

Reaction equation

HRID 1949327 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([N:9]2[C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[C:16]([C:20]#[N:21])[CH:15]=3)=[CH:12][C:11]([C:22]([OH:24])=O)=[N:10]2)[CH:6]=[CH:7][CH:8]=1)#[N:2].C(N(CC)C(C)C)(C)C.ClC1C=C(N2C(C3C=CC=C(OCCO)C=3)=CC(C([N:58]3[CH2:62][C:61](=[O:63])[NH:60][CH2:59]3)=O)=N2)C=CC=1>C(O)=O>[O:63]=[C:61]1[CH2:62][N:58]([C:22]([C:11]2[CH:12]=[C:13]([C:14]3[CH:15]=[C:16]([C:20]#[N:21])[CH:17]=[CH:18][CH:19]=3)[N:9]([C:5]3[CH:4]=[C:3]([C:1]#[N:2])[CH:8]=[CH:7][CH:6]=3)[N:10]=2)=[O:24])[CH2:59][NH:60]1

Participants

5

Reactant 3

HCID 81531DiisopropylethylamineHCID 58277296HCID 58277296, compoundHCID 58277360HCID 58277360, compound

Product 1

HCID 44230248HCID 44230248, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The preparation of the title compound takes place starting from the compound of Example 111A using 3.2 equivalents of N,N-diisopropylethylamine and with the addition of 0.1% formic acid in the preparative HPLC in analogy to the synthesis of the compound of Example 23. 16 mg (29% of theory) of the title compound are obtained.

Sources & evidence

ORD record
ord-04ea1f1cf5d14287acc437040eb8f401
Source dataset
uspto-grants-2013_03
Patent number
US08399682B2

Reaction notes

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