Dimethylformamide → N-(3-tert-butoxycarbonylaminopropyl)-4-cyano-4-(o-tolyl)piperidine

HRID 194935Notes

Reaction equation

HRID 194935 reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[NH:23][CH2:24][CH2:25][CH2:26][Br:27].[C:1](#[N:2])[C:3]1([c:9]2[c:10]([CH3:15])[cH:11][cH:12][cH:13][cH:14]2)[CH2:4][CH2:5][NH:6][CH2:7][CH2:8]1.[CH:28]([N:29]([CH:30]([CH3:31])[CH3:32])[CH2:33][CH3:34])([CH3:35])[CH3:36].[O:37]=[CH:38][N:39]([CH3:40])[CH3:41]>>[C:1](#[N:2])[C:3]1([c:9]2[c:10]([CH3:15])[cH:11][cH:12][cH:13][cH:14]2)[CH2:4][CH2:5][N:6]([CH2:26][CH2:25][CH2:24][NH:23][C:21]([O:20][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:22])[CH2:7][CH2:8]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 4460490tert-butyl N-(3-bromopropyl)carbamateHCID 101765704-o-Tolylpiperidine-4-carbonitrile

Product 1

HCID 21712249N-(3-tert-butoxycarbonylaminopropyl)-4-cyano-4-(o-tolyl)piperidine

Sources & evidence

ORD record
ord-a73aa40b12e84821990f57c4fa03503b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

Loading…