Hydrochloric Acid → HCID 67240003, compound

HRID 1949477Notes

Reaction equation

HRID 1949477 reaction equation
C(OC([N:8]1[CH2:11][CH:10]([C:12](=[O:20])[NH:13][CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])[CH2:9]1)=O)(C)(C)C.[ClH:21]>CO.C1COCC1.O1CCOCC1>[ClH:21].[CH3:19][O:18][C:16](=[O:17])[CH2:15][CH2:14][NH:13][C:12]([CH:10]1[CH2:9][NH:8][CH2:11]1)=[O:20]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 67241283HCID 67241283, compound

Product 1

HCID 67240003HCID 67240003, compoundYield 100%

Reagents, catalysts & solvents 3

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 3-(2-Methoxycarbonyl-ethylcarbamoyl)-azetidine-1-carboxylic acid tert-butyl ester (0.55 g, 1.92 mmol) in MeOH (4 mL) and THF (2 mL) was treated with 4.0N HCl in 1,4-dioxane (4 mL) and stirred at 0° C. for 30 minutes and at room temperature for 5 hours. The solvent was removed in vacuo to yield the title compound as a gum (100%).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-012d4dbbdf6841abb72002e9163fc674
Source dataset
uspto-grants-2013_03
Patent number
US08399681B2

Reaction notes

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