4-Piperidinol, 1-methyl- → HCID 23087228, compound

HRID 1950001Notes

Reaction equation

HRID 1950001 reaction equation
[OH:1]C1CCN(C)CC1.FC1C=C(C=CC=1F)C#N.[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[C:23]#N>>[F:19][C:20]1[CH:21]=[C:22]([CH:25]=[CH:26][C:27]=1[O:28][CH:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1)[CH:23]=[O:1]

Participants

4

Reactant 3

HCID 660484-Piperidinol, 1-methyl-HCID 5872033,4-DifluorobenzonitrileHCID 230874123-Fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile

Product 1

HCID 23087228HCID 23087228, compound

Procedure

Synthesized from 4-hydroxy-1-methylpiperidine and 3,4-difluorobenzonitrile according to an analogous synthetic method to Preparation Example 15, 3-fluoro-4-(1-methylpiperidin-4-yloxy)benzonitrile (1.1 g) was used according to an analogous synthetic method to Preparation Example 16 to provide the title compound (1.1 g).

Workup

  1. customwas used according to an analogous synthetic method to Preparation Example 16

Sources & evidence

ORD record
ord-5180b8cb5d5d4ddfaf4ff088581d6be1
Source dataset
uspto-grants-2013_03
Patent number
US08399520B2

Reaction notes

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