Hydrochloric Acid → HCID 67426793, compound

HRID 1950755Notes

Reaction equation

HRID 1950755 reaction equation
C(OC([CH:8]([NH:35][CH3:36])[CH2:9][O:10][C:11]1[CH:16]=[C:15]([C:17](C)(C)[O:18][SiH2]C(C)(C)C)[CH:14]=[C:13]([C:26](C)(C)[O:27][SiH2]C(C)(C)C)[CH:12]=1)=O)(C)(C)C.[ClH:37]>O1CCOCC1>[ClH:37].[OH:18][CH2:17][C:15]1[CH:16]=[C:11]([O:10][CH2:9][CH2:8][NH:35][CH3:36])[CH:12]=[C:13]([CH2:26][OH:27])[CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131730353HCID 131730353, compound

Product 1

HCID 67426793HCID 67426793, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of 1-(2-(tert-butoxycarbonyl)-methylamino-ethoxy)-3,5-bis-(tert-butyl-dimethyl-silyloxy methyl)-benzene (590 mg) in dioxane (4 mL) was added a solution of hydrochloric acid 4N in dioxane (3.3 mL). After 15 h at rt, the resulting solid was filtered, washed with dioxane and dried in vacuo to give 3,5-bis-hydroxymethyl-(2-methylamino-ethoxy)-benzene hydrochloride (240 mg) as a white powder. LC/MS (Method A2): ES: m/z 212 (M+H)+; RT=0.14 min

Workup

  1. filtrationthe resulting solid was filtered
  2. washwashed with dioxane
  3. customdried in vacuo

Sources & evidence

ORD record
ord-c787deda931c485eaa9a4b88adfb129f
Source dataset
uspto-grants-2013_03
Patent number
US08404678B2

Reaction notes

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