Dimethylformamide dimethyl acetal → HCID 58494269, compound

HRID 1950781Notes

Reaction equation

HRID 1950781 reaction equation
[CH3:1][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=2)[N:5]=[C:4]([S:24][CH3:25])[N:3]=1.CO[CH:28](OC)[N:29]([CH3:31])[CH3:30]>>[CH3:28][N:29]([CH3:31])/[CH:30]=[CH:1]/[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:6]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:21])[F:22])[CH:15]=2)[N:5]=[C:4]([S:24][CH3:25])[N:3]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 58494233HCID 58494233, compound

Product 1

HCID 58494269HCID 58494269, compound

Procedure

The title compound was prepared as described in Example 1e by starting from ethyl 4-methyl-2-(methylthio)-6-(3-(trifluoromethyl)phenylamino)pyrimidine-5-carboxylate 1.76 g (4.74 mmol) and N,N-dimethyl formamide dimethylacetal (947 uL, 7.1 mmol) and continuing until the reaction yielded the crude title compound. This was used for the next step without further purification.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-99e4aa3ef207459b8b0cceb7bb2408c9
Source dataset
uspto-grants-2013_03
Patent number
US08404677B2

Reaction notes

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