Ammonium Hydroxide → HCID 58494179, compound

HRID 1950782Notes

Reaction equation

HRID 1950782 reaction equation
C[N:2](C)/[CH:3]=[CH:4]/[C:5]1[C:10]([C:11](OCC)=[O:12])=[C:9]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:26])([F:25])[F:24])[CH:18]=2)[N:8]=[C:7]([S:27][CH3:28])[N:6]=1.[NH4+].[OH-]>>[CH3:28][S:27][C:7]1[N:8]=[C:9]([NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([C:23]([F:24])([F:25])[F:26])[CH:18]=2)[C:10]2[C:11](=[O:12])[NH:2][CH:3]=[CH:4][C:5]=2[N:6]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 58494269HCID 58494269, compound

Product 1

HCID 58494179HCID 58494179, compound

Procedure

The title compound was prepared as described in Example 1f by starting from (E)-ethyl 4-(2-(dimethylamino)vinyl)-2-(methylthio)-6-(3-(trifluoromethyl)phenylamino)pyrimidine-5-carboxylate and 30% NH4OH solution and continuing until the reaction yield brown solids, 2-(methylthio)-4-(3-(trifluoro methyl)phenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one (912 mg). MS m/z: 353.1 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-a33bf1d48a8e4d8a94ecce06a07c7c03
Source dataset
uspto-grants-2013_03
Patent number
US08404677B2

Reaction notes

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