Ammonium Hydroxide → HCID 86658934, compound

HRID 1950787Notes

Reaction equation

HRID 1950787 reaction equation
[F:1][C:2]([F:33])([F:32])[C:3]1[CH:4]=[C:5]([NH:13][C:14]2[C:19]([C:20]([O:22]CC)=O)=[C:18](/[CH:25]=[CH:26]/[N:27](C)C)[N:17]=[C:16]([S:30][CH3:31])[N:15]=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[NH4+].[OH-]>>[F:10][C:9]([F:11])([F:12])[C:7]1[CH:6]=[C:5]([NH:13][C:14]2[C:19]3[C:20](=[O:22])[NH:27][CH:26]=[CH:25][C:18]=3[N:17]=[C:16]([S:30][CH3:31])[N:15]=2)[CH:4]=[C:3]([C:2]([F:1])([F:33])[F:32])[CH:8]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 86658935HCID 86658935, compound

Product 1

HCID 86658934HCID 86658934, compound

Procedure

The title compound was prepared as described in Example 1f by starting from (E)-ethyl 4-(3,5-bis(trifluoromethyl)phenylamino)-6-(2-(dimethylamino)vinyl)-2-(methylthio)pyrimidine-5-carboxylate and aq. NH4OH solution and continuing until the reaction yielded pale yellow solids, title compound (537 mg). MS m/z: 421.1 (M+1)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-d0f01aa0355540a39840999dd45fc6e7
Source dataset
uspto-grants-2013_03
Patent number
US08404677B2

Reaction notes

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