Piperidin-4-ol → HCID 58494270, compound

HRID 1950793Notes

Reaction equation

HRID 1950793 reaction equation
Br[C:2]1[C:7]2[N:8]=[C:9](SC)[N:10]=[C:11]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[C:6]=2[C:5](=[O:25])[NH:4][CH:3]=1.[OH:26][CH:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1>>[OH:26][CH:27]1[CH2:32][CH2:31][N:30]([C:9]2[N:10]=[C:11]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[C:6]3[C:5](=[O:25])[NH:4][CH:3]=[CH:2][C:7]=3[N:8]=2)[CH2:29][CH2:28]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 58494211HCID 58494211, compound

Product 1

HCID 58494270HCID 58494270, compoundYield 60%

Procedure

The title compound was prepared as described in Example 1g by starting from 8-bromo-2-(methylthio)-4-(3-(trifluoromethyl)phenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one (60 mg, 0.26 mmol) and 4-hydroxypiperidine and continuing until the reaction yielded the title compound (40 mg, 60%)) as grey solid. MS m/z: 484 and 486 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-f81a76e25e4844bba5e2731fdfc28352
Source dataset
uspto-grants-2013_03
Patent number
US08404677B2

Reaction notes

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