反应详情

温度

0 °C

To a stirred, cooled (0° C.) solution of Z-Beta-Ala-OH (1.784 g, 8.0 mmol) in dioxane (20 ml) is added EDCI.HCl (2.145 g, 11.2 mmol), hydroxybenzotriazole (1.08 g, 8.0 mmol) and triethylamine (1.56 ml, 11.2 mmol). After stirring at 0° C. for 30 minutes, dimethylamine (0.397 g, 8.8 mmol) is added and stirring continued for a further hour. The reaction mixture was allowed to warm to room temperature and the solvent is removed in vacuo. Initial purification of the crude residue is carried out by flash chromatography of silica eluting with ethyl acetate. The combined organic factions are washed with water (3×20 ml), brine (1×50 ml) and dried over MgSO4. The solvent is removed in vacuo to yield the titled compound as a pale yellow solid.

1. stirringstirring
2. waitcontinued for a further hour
3. temperatureto warm to room temperature
4. customthe solvent is removed in vacuo
5. customInitial purification of the crude residue
6. washThe combined organic factions are washed with water (3×20 ml), brine (1×50 ml)
7. dry with materialdried over MgSO4
8. customThe solvent is removed in vacuo