反应详情

温度

75 °C

A stirred suspension of 4-methyl-5-(2-morpholin-4-yl-pyridin-4-yl)-thiazol-2-ylamine hydrobromide (13b) (0.035 g, 0.098 mmol) and ethyldiisopropylamine (0.034 ml, 0.196 mmol) in acetic anhydride (2 ml) is heated to 75° C. for 2 hours. The reaction mixture is cooled to room temperature and the solvent is removed in vacuo. Ethyl acetate is added and a white solid by-product is filtered off. The filtrate is concentrated in vacuo to afford the titled compound as a white solid.

1. temperatureThe reaction mixture is cooled to room temperature
2. customthe solvent is removed in vacuo
3. additionEthyl acetate is added
4. filtrationa white solid by-product is filtered off
5. concentrationThe filtrate is concentrated in vacuo