Triethylamine → HCID 59185808, compound

HRID 1951245Notes

Reaction equation

HRID 1951245 reaction equation
Cl[CH2:2][CH2:3][NH:4][C:5]([C:7]1[NH:8][C:9]([CH3:16])=[C:10]([C:13](=[O:15])[CH3:14])[C:11]=1[CH3:12])=[O:6].CCN(CC)CC>C(Cl)Cl>[C:13]([C:10]1[C:11]([CH3:12])=[C:7]2[C:5](=[O:6])[NH:4][CH2:3][CH2:2][N:8]2[C:9]=1[CH3:16])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 59185796HCID 59185796, compound

Product 1

HCID 59185808HCID 59185808, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

4-Acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid (2-chloro-ethyl)-amide (12.664 g, 52.18 mmol) was slurried in DCM (100 mL) and Et3N (20 mL) and heated to 50° C. for 16 hours. After cooling to room temperature and removal of solvent, the residue was treated with cold water. The resulting off white precipitate filtered off and shown to be the target compound (10.424 g, 50.54 mmol, 97% yield).

Workup

  1. customremoval of solvent
  2. additionthe residue was treated with cold water
  3. filtrationThe resulting off white precipitate filtered off

Sources & evidence

ORD record
ord-d31ce34f38784c30b1a04eb1acbe6237
Source dataset
uspto-grants-2013_03
Patent number
US08404692B2

Reaction notes

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