Hydrochloric Acid → HCID 45377209, compound

HRID 1951484Notes

Reaction equation

HRID 1951484 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:11])=[O:10])=[CH:4][C:3]=1[NH:18][CH:19]1[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]1.Cl>C(OCC)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)(=[O:11])=[O:10])=[CH:4][C:3]=1[NH:18][CH:19]1[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 45377063HCID 45377063, compound

Product 1

HCID 45377209HCID 45377209, compoundYield 169.8%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
27.5 °C

Procedure

The product (0.86 grams) obtained from Example 1 was converted into its hydrochloride salt by using the following procedure. The obtained base was taken into diethyl ether (25 mL) and added 1 mL of 10% isopropanolic hydrogen chloride. The reaction mass was stirred for 3 hours at 25-30° C. and filtered the hydrochloride salt to obtain the title product (0.8 grams).

Workup

  1. filtrationfiltered the hydrochloride salt

Sources & evidence

ORD record
ord-4d64d20eb3784378b275e1c5a86da2f5
Source dataset
uspto-grants-2013_03
Patent number
US08404720B2

Reaction notes

Loading…