反应详情

A mixture of 0.35 g of the product of Step 6 was dissolved in 15 ml THF, 10 ml of MeOH and 5 ml of water, followed by 5 ml of 1N aqueous LiOH solution. After stirring for 5 h at room temperature, 1 ml of AcOH was added and the mixture was extracted with 50 ml of EtOAc. The organic layer was washed with 25 ml of brine and dried over Na2SO4, filtered, and concentrated to give 0.30 g of the title compound as a white solid.

1. extractionthe mixture was extracted with 50 ml of EtOAc
2. washThe organic layer was washed with 25 ml of brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated