Water → HCID 57475093, compound

HRID 1951760Notes

Reaction equation

HRID 1951760 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[O:8]1[C:12]2([CH2:17][CH2:16][C:15](=O)[CH2:14][CH2:13]2)[O:11][CH2:10][CH2:9]1.[NH:19]1[CH:23]=[CH:22][N:21]=[N:20]1.O>C1(C)C=CC=CC=1>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:15]2([N:19]3[CH:23]=[CH:22][N:21]=[N:20]3)[CH2:16][CH2:17][C:12]3([O:11][CH2:10][CH2:9][O:8]3)[CH2:13][CH2:14]2)[CH2:4][CH2:3]1

Participants

6

Reactant 4

HCID 962WaterHCID 531671-MethylpiperazineHCID 5674151,4-Dioxaspiro[4.5]decan-8-oneHCID 178418936HCID 178418936, compound

Product 1

HCID 57475093HCID 57475093, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In a thoroughly heated flask, a solution of N-methylpiperazine (2.60 g, 2.88 ml, 26 mmol), 1,4-dioxaspiro[4.5]decan-8-one (3.90 g, 25 mmol) and 1,2,3-triazole (1.87 g, 27 mmol) in toluene (25 ml) was heated for 6 h under reflux in a water separator. The reaction solution was then transferred to a closable measuring cylinder and the crude product was used further in.

Sources & evidence

ORD record
ord-c34594f8b07649b997e5f92454faa617
Source dataset
uspto-grants-2013_03
Patent number
US08404740B2

Reaction notes

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