Carbon Dioxide → HCID 427138, compound

HRID 1951921Notes

Reaction equation

HRID 1951921 reaction equation
[CH2:1]1[S:5][CH2:4][NH:3][CH:2]1[C:6]([OH:8])=[O:7].[C:9](=O)=O.Cl>C=O.C(O)=O>[CH3:9][N:3]1[CH:2]([C:6]([OH:8])=[O:7])[CH2:1][S:5][CH2:4]1

Participants

6

Reactant 3

HCID 280Carbon DioxideHCID 313Hydrochloric AcidHCID 9934Timonacic

Product 1

HCID 427138HCID 427138, compound

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 712FormaldehydeSolvent

Conditions

Temperature
80 °C

Procedure

L-thiazolidine-4-carboxylic acid (13.3 g) in a mixture of 37% formaldehyde (22.5 ml) and 96% formic acid (39.3 ml) was heated to 80° C. After one hour CO2 evolution ceased. The heating was continued until most of the solvent was removed. The residue was dissolved in methanol and evaporated on the rotovap three times. One equivalent of concentrated hydrochloric acid was added and the resulting salt crystallized from methanol and ethyl ether. Yield 17.0 g (92%).

Workup

  1. customwas removed
  2. dissolutionThe residue was dissolved in methanol
  3. customevaporated on the rotovap three times
  4. customthe resulting salt crystallized from methanol and ethyl ether

Sources & evidence

ORD record
ord-49fb729e5eeb41eba566062a75042b47
Source dataset
uspto-grants-2013_03
Patent number
US08404804B2

Reaction notes

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