Diethylamine → HCID 178464498, compound

HRID 1952411Notes

Reaction equation

HRID 1952411 reaction equation
[C:1]1([P:7]([Cl:9])[Cl:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:10]([NH:12][CH2:13][CH3:14])[CH3:11]>C1(C)C=CC=CC=1>[CH2:10]([N:12]([CH2:13][CH3:14])[PH:7]([Cl:9])([Cl:8])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH3:11]

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 12573Phenyl phosphorus dichloride

Product 1

HCID 178464498HCID 178464498, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
0 °C

Procedure

Phenyldichlorophosphine (4.47 g, 25.0 mmol) was dissolved in 80 mL of toluene and then cooled to 0° C. under N2. Diethylamine (3.65 g, 50.0 mmol) was added dropwise and the resulting reaction mixture was allowed to warm-up to room temperature (ca. 20° C.) overnight (ca. 12 hrs). Reaction was then filtered and the liquid phase was concentrated to give 5.25 g (97% yield) of N,N-diethyl-phenylphosphoramidous chloride.

Workup

  1. customthe resulting reaction mixture
  2. temperatureto warm-up to room temperature (ca. 20° C.) overnight (ca. 12 hrs)
  3. customReaction
  4. filtrationwas then filtered
  5. concentrationthe liquid phase was concentrated

Sources & evidence

ORD record
ord-79abf5861f0e4c08964023bfbd66c697
Source dataset
uspto-grants-2013_03
Patent number
US08404915B2

Reaction notes

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