Trifluoroacetic acid → HCID 86671260, compound

HRID 1952583Notes

Reaction equation

HRID 1952583 reaction equation
[CH3:1][O:2][C:3](=[O:37])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:26](=[O:36])[NH:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([OH:35])[CH:30]=2)=[CH:20][C:21]=1[C:22]([F:25])([F:24])[F:23])=[O:16])[CH2:5][NH:6]C(OC(C)(C)C)=O.[C:38]([OH:44])([C:40]([F:43])([F:42])[F:41])=[O:39]>C(Cl)Cl>[F:41][C:40]([F:43])([F:42])[C:38]([OH:44])=[O:39].[CH3:1][O:2][C:3](=[O:37])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:26](=[O:36])[NH:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[C:31]([OH:35])[CH:30]=2)=[CH:20][C:21]=1[C:22]([F:25])([F:23])[F:24])=[O:16])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68226430HCID 68226430, compound

Product 1

HCID 86671260HCID 86671260, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-3-tert-Butoxycarbonylamino-2-{[5-(3-hydroxy-benzylcarbamoyl)-3-trifluoromethyl-thiophene-2-carbonyl]-amino}-propionic acid methyl ester (0.19 g, 0.34 mmol) in DCM (6 mL) was added TFA (3.0 mL). The mixture was stirred at room temperature 1 h and evaporated. Isolate 0.23 g of crude product which was used without further purification.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-82aef08293c046f8b7eacbf97139e019
Source dataset
uspto-grants-2013_03
Patent number
US08404859B2

Reaction notes

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