Trifluoroacetic acid → HCID 86671262, compound

HRID 1952603Notes

Reaction equation

HRID 1952603 reaction equation
[CH3:1][O:2][C:3](=[O:40])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:26](=[O:39])[NH:27][CH2:28][C:29]2[CH:37]=[CH:36][CH:35]=[C:34]3[C:30]=2[CH2:31][C:32](=[O:38])[NH:33]3)=[CH:20][C:21]=1[C:22]([F:25])([F:24])[F:23])=[O:16])[CH2:5][NH:6]C(OC(C)(C)C)=O.[C:41]([OH:47])([C:43]([F:46])([F:45])[F:44])=[O:42]>C(Cl)Cl>[F:44][C:43]([F:46])([F:45])[C:41]([OH:47])=[O:42].[CH3:1][O:2][C:3](=[O:40])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:26](=[O:39])[NH:27][CH2:28][C:29]2[CH:37]=[CH:36][CH:35]=[C:34]3[C:30]=2[CH2:31][C:32](=[O:38])[NH:33]3)=[CH:20][C:21]=1[C:22]([F:24])([F:25])[F:23])=[O:16])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68226516HCID 68226516, compound

Product 1

HCID 86671262HCID 86671262, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-3-tert-Butoxycarbonylamino-2-({5-[(2-oxo-2,3-dihydro-1H-indol-4-ylmethyl)-carbamoyl]-3-trifluoromethyl-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (0.10 g, 0.17 mmol) in DCM (5 mL) was added TFA (1.5 mL). The mixture was stirred at room temperature 1 h and evaporated. Isolate 0.14 g of crude product which was used without further purification.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-7b245f3429b54ffaa0528bc0401f6070
Source dataset
uspto-grants-2013_03
Patent number
US08404859B2

Reaction notes

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