Trifluoroacetic acid → HCID 68226469, compound

HRID 1952606Notes

Reaction equation

HRID 1952606 reaction equation
[CH3:1][O:2][C:3](=[O:36])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:23](=[O:35])[NH:24][CH2:25][C:26]2[CH:34]=[CH:33][CH:32]=[C:31]3[C:27]=2[CH:28]=[N:29][NH:30]3)=[CH:20][C:21]=1[Cl:22])=[O:16])[CH2:5][NH:6]C(OC(C)(C)C)=O.[C:37]([OH:43])([C:39]([F:42])([F:41])[F:40])=[O:38]>C(Cl)Cl>[F:40][C:39]([F:42])([F:41])[C:37]([OH:43])=[O:38].[CH3:1][O:2][C:3](=[O:36])[C@@H:4]([NH:14][C:15]([C:17]1[S:18][C:19]([C:23](=[O:35])[NH:24][CH2:25][C:26]2[CH:34]=[CH:33][CH:32]=[C:31]3[C:27]=2[CH:28]=[N:29][NH:30]3)=[CH:20][C:21]=1[Cl:22])=[O:16])[CH2:5][NH2:6]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68226560HCID 68226560, compound

Product 1

HCID 68226469HCID 68226469, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of (S)-3-tert-Butoxycarbonylamino-2-({3-chloro-5-[(1H-indazol-4-ylmethyl)-carbamoyl]-thiophene-2-carbonyl}-amino)-propionic acid methyl ester (0.1015 g, 0.19 mmol) in DCM (5 mL) was added TFA (1 mL). The mixture was stirred at room temperature 2 h and evaporated. Isolate 0.127 g of crude product which was used without further purification.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-7eb4ebdddcda472ab927ba7f2942f9b9
Source dataset
uspto-grants-2013_03
Patent number
US08404859B2

Reaction notes

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