反应详情

温度

115 °C

A mixture of 3-Bromo-5-bromomethyl-thiophene-2-carboxylic acid methyl ester (0.99 g, 3.15 mmol) and NaHCO3 (4.5 g, 53.6 mmol) in DMSO (25 ml) was heated at 115° C. for 3 h. The reaction mixture was cooled. The reaction mixture was EtOAc (250 ml), washed with brine, dried over sodium sulfate, filtered and evaporated. The residue was purified by column (0-30% EtOAc in hexane) to give 0.19 g (24%) yellow solid product.

1. temperatureThe reaction mixture was cooled
2. washwashed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by column (0-30% EtOAc in hexane)