反应详情

温度

70 °C

A mixture of 5-Bromomethyl-3-cyano-thiophene-2-carboxylic acid methyl ester (0.89 g, 3.42 mmol) and water (15 ml) in THF (2 ml) was heated at 70° C. for 2 d. The reaction mixture was cooled. The reaction mixture was poured into EtOAc (50 ml), washed with brine, dried over sodium sulfate, filtered and evaporated. The residue was purified by column (0-40% EtOAc in hexane) to give 0.1114 g (17%) yellow solid product.

1. temperatureThe reaction mixture was cooled
2. washwashed with brine
3. dry with materialdried over sodium sulfate
4. filtrationfiltered
5. customevaporated
6. customThe residue was purified by column (0-40% EtOAc in hexane)