Hydrochloric Acid → HCID 88178204, compound

HRID 1952811Notes

Reaction equation

HRID 1952811 reaction equation
[ClH:1].[OH:2][CH2:3][CH2:4][N:5]([CH2:41][CH2:42][OH:43])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH:21]=[O:22])=[O:11]>C(OCC)(=O)C.C(Cl)(Cl)Cl>[ClH:1].[OH:2][CH2:3][CH2:4][N:5]([CH2:41][CH2:42][OH:43])[CH2:6][CH2:7][CH2:8][NH:9][C:10]([O:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[N:20]([CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40])[CH:21]=[O:22])=[O:11]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54104049HCID 54104049, compound

Product 1

HCID 88178204HCID 88178204, compound

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8857Ethyl AcetateSolvent2×

Procedure

4N Hydrochloric acid--ethyl acetate solution (0.20 ml) was added to a solution of [2-[[N-[3-[bis(2-hydroxyethyl)amino]propyl]carbamoyloxy]methyl]phenyl]-N-octadecyl formamide (0.47 g) in a mixture of ethyl acetate (5 ml) and chloroform (2 ml) at room temperature. After being stirred for 10 minutes, the reaction mixture was concentrated. The residue was recrystallized from ethyl acetate-ethanol-chloroform mixed solvent, thereby yielding 0.44 g of the aimed compound as white crystals.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customThe residue was recrystallized from ethyl acetate-ethanol-chloroform mixed solvent

Sources & evidence

ORD record
ord-e0b41d0e75184d5a951d6a99f366640b
Source dataset
uspto-grants-2000_09
Patent number
US06114325

Reaction notes

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