Ammonium formate → HCID 9926403, compound

HRID 1952834Notes

Reaction equation

HRID 1952834 reaction equation
[C:1]1([C:7]2[NH:8][C:9]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[C:10]3[C:15]=2[CH2:14][C:13]([CH3:16])=[C:12]([CH3:17])[CH2:11]3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])=O.[NH4+]>C(O)C.[Pd]>[C:18]1([C:9]2[NH:8][C:7]([C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)=[C:15]3[C:10]=2[CH2:11][CH:12]([CH3:17])[CH:13]([CH3:16])[CH2:14]3)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

5

Reactant 2

HCID 2723923Ammonium formateHCID 10494397HCID 10494397, compound

Product 1

HCID 9926403HCID 9926403, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1 g of the product obtained in Example 6, 1.2 g of ammonium format and 0.2 g of 10% Pd/C in 70 ml of ethanol are heated at reflux for 3 hours, then filtered and concentrated. The expected product is isolated by chromatography on silica gel (eluant: cyclohexane/ethyl acetate: 90/10).

Workup

  1. temperatureat reflux for 3 hours
  2. filtrationfiltered
  3. concentrationconcentrated

Sources & evidence

ORD record
ord-2ce35f2c1a7f4144be33a13d7e0a8aad
Source dataset
uspto-grants-2000_09
Patent number
US06114360

Reaction notes

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