Hydrochloric Acid → HCID 131721967, compound

HRID 1952839Notes

Reaction equation

HRID 1952839 reaction equation
[N:1]1(C(OC(C)(C)C)=O)[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([OH:9])=[O:8].[ClH:17].[CH3:18]O>O1CCOCC1>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([O:9][CH3:18])=[O:8].[ClH:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 1044121,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-dimethylethyl) ester, (2S)-

Product 1

HCID 131721967HCID 131721967, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

N-Boc-Pyr-OH (5 g, 23.45 mmol) was dissolved in MeOH (50 ml), and HCl in dioxane (4N, 30 ml) was added. After refluxing for 12 h, the solvent was removed in a rotary evaporator and H-Pyr-OMe hydrochloride was obtained as product. Yield: 3.84 g (100%).

Workup

  1. temperatureAfter refluxing for 12 h
  2. customthe solvent was removed in a rotary evaporator

Sources & evidence

ORD record
ord-d799be9a3a4948f4a2db49d04e5bc6c1
Source dataset
uspto-grants-2000_09
Patent number
US06114358

Reaction notes

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