反应详情

A mixture of 106.3 g (0.489 mol) of ethyl 4,4-diethoxypentanoate and 80 ml (73.6 g, 0.99 mol) of ethyl formate was added dropwise to a vigorously stirred suspension of 12.7 g (0.55 gram atom) of sodium (shavings) in 300 ml of anhydrous benzene at 10-15° C. over 3 h. Stirring was continued for a further 3 h, and the reaction mixture was left to stand overnight. 250 ml of water were added with vigorous stirring, and this was continued for a further 15 min. The water layer was separated off, and the benzene layer was extracted with 70 ml of water. The combined aqueous extracts were acidified to pH 2 and extracted with ethyl acetate (5×50 ml), and the organic extracts were dried over calcium chloride.

1. waitthe reaction mixture was left
2. waitto stand overnight
3. waitthis was continued for a further 15 min
4. customThe water layer was separated off
5. extractionthe benzene layer was extracted with 70 ml of water
6. extractionextracted with ethyl acetate (5×50 ml)
7. dry with materialthe organic extracts were dried over calcium chloride