Hydrochloric Acid → HCID 14585930, compound

HRID 1952975Notes

Reaction equation

HRID 1952975 reaction equation
[C:1]([CH:3](C#N)[CH2:4][NH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH:16](C#N)[C:17]#[N:18])#[N:2].[H][H].[ClH:25]>O=[Pt]=O>[ClH:25].[ClH:25].[ClH:25].[ClH:25].[NH2:18][CH2:17][CH2:16][CH2:15][NH:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][NH:5][CH2:4][CH2:3][CH2:1][NH2:2]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 85571652HCID 85571652, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 14585930HCID 14585930, compound

Reagents, catalysts & solvents 1

HCID 345198Adams' catalystCatalyst

Procedure

Combine N,N'-bis-[2,2'-bis(cyano)ethyl]-1,8-diamino-octane (50 g) with PtO2 (2.0 g) in concentrated hydrochloric acid (133 mL). Place in a shaker flask at 45 lbs./sq. in. until hydrogen is no longer taken up. Filter the mixture and remove the solvent under vacuum. Triturate the residue with ethanol (1 L). Collect the product by filtration and dry the product to provide 1,5,14,18-tetraazaoctadecane tetrahydrochloride (51.6 g), Rf =0.17 eluting with 40% NH3 /methanol.

Workup

  1. filtrationFilter the mixture
  2. customremove the solvent under vacuum
  3. customTriturate the residue with ethanol (1 L)
  4. customCollect the product
  5. filtrationby filtration
  6. customdry the product

Sources & evidence

ORD record
ord-9716dac0ad9946d2920710d0d72b69a3
Source dataset
uspto-grants-2000_09
Patent number
US06114394

Reaction notes

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