Hydrochloric Acid → 4-(2-(Aminocarbonyl)ethyl]benzenemethanamine

HRID 1953010Notes

Reaction equation

HRID 1953010 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][C:11]([NH2:13])=[O:12])=[CH:5][CH:4]=1)#[N:2].Cl>[Pd].C(OCC)C>[NH2:13][C:11]([CH2:10][CH2:9][C:6]1[CH:7]=[CH:8][C:3]([CH2:1][NH2:2])=[CH:4][CH:5]=1)=[O:12]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 233017673-(4-Cyanophenyl)propanamide

Product 1

HCID 233018594-(2-(Aminocarbonyl)ethyl]benzenemethanamineYield 88%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 3283Diethyl EtherSolvent

Procedure

Prepared analogously to Example 43b) from 4-cyanobenzenepropanamide by catalytic hydrogenation using palladium/activated charcoal and in the presence of 1 equivalent of 2N hydrochloric acid in a yield of 88% of theory. Colourless crystals (diethylether).

Sources & evidence

ORD record
ord-f29a4f9bbb4b437a946660ba3f8f408e
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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