HCID 54357069, compound → HCID 23301812, compound

HRID 1953025Notes

Reaction equation

HRID 1953025 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][C:17]([O:19]CC2C=CC=CC=2)=[O:18])=[CH:8]1)=[O:5])[CH3:2]>[Pd].O1CCCC1>[CH2:1]([O:3][C:4]([CH2:6][N:7]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9]([CH2:16][C:17]([OH:19])=[O:18])=[CH:8]1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 54357069HCID 54357069, compound

Product 1

HCID 23301812HCID 23301812, compoundYield 60%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 45f), but using tetrahydrofuran instead of ethanol as solvent, from phenylmethyl 1-(ethoxycarbonylmethyl)-1H-indole-3-acetate by catalytic hydrogenation in the presence of palladium/activated charcoal in a yield of 60% of theory. Colourless crystal, Mp. 138° C.

Workup

  1. customPrepared analogously to Example 45f), but

Sources & evidence

ORD record
ord-3a06b595cf3e4e7c8674dd164c736fe7
Source dataset
uspto-grants-2000_09
Patent number
US06114390

Reaction notes

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