Methyl chloroformate → HCID 54069346, compound

HRID 1953290Notes

Reaction equation

HRID 1953290 reaction equation
Cl.[CH2:2]([O:4][C:5]([CH2:7][N:8]([S:29]([C:32]1[CH:33]=[CH:34][CH:35]=[C:36]2[C:41]=1[N:40]=[CH:39][CH:38]=[CH:37]2)(=[O:31])=[O:30])[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[C:13]([CH2:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH2:26])=[NH:25])=[CH:22][CH:21]=1)=[CH:12]2)=[O:6])[CH3:3].Cl[C:43]([O:45][CH3:46])=[O:44].C(=O)([O-])[O-].[K+].[K+]>O1CCCC1>[CH2:2]([O:4][C:5]([CH2:7][N:8]([S:29]([C:32]1[CH:33]=[CH:34][CH:35]=[C:36]2[C:41]=1[N:40]=[CH:39][CH:38]=[CH:37]2)(=[O:30])=[O:31])[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH3:18])[C:13]([CH2:19][C:20]1[CH:21]=[CH:22][C:23]([C:24]([NH2:26])=[N:25][C:43]([O:45][CH3:46])=[O:44])=[CH:27][CH:28]=1)=[CH:12]2)=[O:6])[CH3:3]

Participants

5

Reactant 3

HCID 6586Methyl chloroformateHCID 11430Potassium CarbonateHCID 23302257HCID 23302257, compound

Product 1

HCID 54069346HCID 54069346, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared analogously to Example 97 from 4-[(5-(N-ethoxycarbonylmethyl-quinolin-8-yl-sulphonylamino)-1-methyl-indol-2-yl)-methyl]-benzamidine-hydrochloride, methyl chloroformate and potassium carbonate in tetrahydrofuran.

Sources & evidence

ORD record
ord-c48913da3f60438280afde7090821244
Source dataset
uspto-grants-2000_09
Patent number
US06114532

Reaction notes

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