7-Methylisatin → 3-(Benzyloxyimino)-7-methylindolin-2-one

HRID 1953314Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1953314
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2=O.Cl.[CH2:14]([O:21][NH2:22])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C([O-])(=O)C.[Na+]>C(O)C.O>[CH2:14]([O:21][N:22]=[C:7]1[C:6]2[C:10](=[C:2]([CH3:1])[CH:3]=[CH:4][CH:5]=2)[NH:9][C:8]1=[O:11])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Komponenten

6

Edukt 3

HCID 143137-MethylisatinHCID 102312Benzyloxyamine hydrochlorideHCID 517045Sodium Acetate

Produkt 1

HCID 1361447423-(Benzyloxyimino)-7-methylindolin-2-oneAusbeute 68 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 962WaterLösungsmittel

Versuchsvorschrift

To a suspension of 4.91 g of 7-methylisatin in 100 ml of ethanol was added a solution of 5.59 g of O-benzylhydroxylamine hydrochloride and 3.29 g of sodium acetate in 40 ml of water at room temperature. The mixture was stirred at room temperature for 3 hours and concentrated. The concentrate was diluted with chloroform and washed with water. The organic layer was dried over anhydrous sodium sulfate and concentrated. Recrystallization of the crude product from benzene yielded 5.40 g (68%) of the title compound.

Aufarbeitung

  1. concentrationconcentrated
  2. additionThe concentrate was diluted with chloroform
  3. washwashed with water
  4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
  5. concentrationconcentrated
  6. customRecrystallization of the crude product from benzene

Quellen und Nachweise

ORD-Eintrag
ord-545fbc2eabe74b4587c96dac4a9db421
Quelldatensatz
uspto-grants-2000_09
Patentnummer
US06114536

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