反应详情

温度

120 °C

6-Aminohexanoic acid (1.47 g, 11.2 mmol) was added to a solution of 9-phenoxyacridine (2.7 g, 10 mmol) in phenol (15 g). The suspension was stirred at 120° C. for 2 h. The solution was cooled to room temperature and poured into ether whereby the product precipitated as a yellow-green solid. It was triturated with hot ethanol, filtered then washed with ethanol, giving crude 9-(5-carboxypentyl) aminoacridine.Yield 2.4 g (78%).

1. temperatureThe solution was cooled to room temperature
2. customprecipitated as a yellow-green solid
3. customIt was triturated with hot ethanol
4. filtrationfiltered
5. washthen washed with ethanol