Trityl chloride → HCID 23298218, compound

HRID 1953839Notes

Reaction equation

HRID 1953839 reaction equation
[CH2:1]([C:3]1[C:12]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[N:27]=[N:28][NH:29][N:30]=3)=[CH:16][CH:15]=2)=[C:11]([C:31]([OH:33])=[O:32])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[CH3:2].[Li][Li].C(N(CC)CC)C.[C:43]1([C:49](Cl)([C:56]2[CH:61]=[CH:60][CH:59]=[CH:58][CH:57]=2)[C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=1>CC(C)=O>[CH2:1]([C:3]1[C:12]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[N:27]=[N:28][N:29]([C:49]([C:43]4[CH:48]=[CH:47][CH:46]=[CH:45][CH:44]=4)([C:56]4[CH:57]=[CH:58][CH:59]=[CH:60][CH:61]=4)[C:50]4[CH:51]=[CH:52][CH:53]=[CH:54][CH:55]=4)[N:30]=3)=[CH:16][CH:15]=2)=[C:11]([C:31]([OH:33])=[O:32])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)[CH3:2]

Participants

6

Reactant 4

HCID 6456Trityl chlorideHCID 8471TriethylamineHCID 139759Lithium, mol. (Li2)HCID 9846347HCID 9846347, compound

Product 1

HCID 23298218HCID 23298218, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of the title compound of Example 2, 2-ethyl-3-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]-oxy]-4-quinolinecarboxylic acid, dilithium salt (700 mg, 1.6 mmol), triethyl amine (245 microliters, 1.76 mmol), triphenylmethyl chloride (468 mg, 1.68 mmol) and acetone (8 mL) was stirred at room temperature for 36 hours. The mixture was concentrated in vacuo to yield the crude product as a waxy solid (1.35 g, 100%).

Sources & evidence

ORD record
ord-2615ce54bdce4d7b86bad8d14efa13a2
Source dataset
uspto-grants-2000_09
Patent number
US06117885

Reaction notes

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