反应详情

Compound 27 was suspended in water (2 ml) and ethanol (6 ml), and the suspension was added with concentrated hydrochloric acid (0.5 ml). The mixture was added with iron powder (220 mg) and then heated under reflux for 30 minutes. The reaction mixture was filtered to remove solid materials and the filtrate was extracted with ethyl acetate. The organic layer was washed with water and saturated brine and dried, and the solvent was then evaporated under reduced pressure to give o-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphtalenyl)-2-aminophenol (Compound 28, 80.5 mg, 85%).

1. temperatureheated
2. temperatureunder reflux for 30 minutes
3. filtrationThe reaction mixture was filtered
4. customto remove solid materials
5. extractionthe filtrate was extracted with ethyl acetate
6. washThe organic layer was washed with water and saturated brine
7. customdried
8. customthe solvent was then evaporated under reduced pressure