反应详情

温度

60 °C

23.8 g of methyl 3-hydroxy-4-methoxybenzoate are dissolved in 200 ml of anhydrous DMF and the solution is treated with 35 g of potassium carbonate (ground) and 13 ml of 2-chlorocyclopentanone. The mixture is stirred at 60° C. for 3 h, then the solid is filtered off with suction and the filtrate is concentrated in vacuo. The residue is chromatographed on a silica gel column using ethyl acetate/petroleum ether (4:6). The chromatographically pure fractions are combined, concentrated and dried in a high vacuum. 24.3 g of the title compound are obtained as a pale yellow oil.

1. filtrationthe solid is filtered off with suction
2. concentrationthe filtrate is concentrated in vacuo
3. customThe residue is chromatographed on a silica gel column
4. concentrationconcentrated
5. customdried in a high vacuum