反应详情

A solution of 1-(12-Tridecenyl)-3,7-dimethylxanthine (1.39 g, 3.86 mmol), 4-methylmorpholine-N-oxide (1.36 g, 11.6 mmol) and potassium osmate dihydrate (14 mg, 0.040 mmol) in acetone/water 1:2 (25 mL) was stirred for 16 hours. Water (25 mL) and sodium sulfite (2 g) were added and the reaction mixture stirred for 1 hour. The reaction mixture was extracted with dichloromethane (3×50 mL), dried using magnesium sulfate and the solvent evaporated to yield 1.25 g (82%) of 1-(12,13-dihydroxytridecyl)-3,7-dimethylxanthine (inventive compound no. 2556) as a white solid.

1. extractionThe reaction mixture was extracted with dichloromethane (3×50 mL)
2. customdried
3. customthe solvent evaporated