Tetrahydrofuran → Benzyl 4-{4-[3-(2,5-difluorophenylamino)propoxy]phenyl}-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]piperidinecarboxylate
Reaction equation
[F:41][c:42]1[c:43]([NH:49][CH2:50][CH2:51][CH2:52][OH:53])[cH:44][c:45]([F:48])[cH:46][cH:47]1.[O:73]=[C:74]([O:75][CH:76]([CH3:77])[CH3:78])[N:79]=[N:80][C:81]([O:82][CH:83]([CH3:84])[CH3:85])=[O:86].[O:87]1[CH2:88][CH2:89][CH2:90][CH2:91]1.[OH:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([O:24][CH2:25][c:26]3[cH:27][cH:28][c:29]4[c:30]([cH:40]3)[N:31]([CH2:35][CH2:36][CH2:37][O:38][CH3:39])[CH2:32][CH2:33][O:34]4)[CH2:10][N:11]([C:14](=[O:15])[O:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1.[c:54]1([P:55]([c:56]2[cH:57][cH:58][cH:59][cH:60][cH:61]2)[c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[cH:68][cH:69][cH:70][cH:71][cH:72]1>>[O:1]([c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([O:24][CH2:25][c:26]3[cH:27][cH:28][c:29]4[c:30]([cH:40]3)[N:31]([CH2:35][CH2:36][CH2:37][O:38][CH3:39])[CH2:32][CH2:33][O:34]4)[CH2:10][N:11]([C:14](=[O:15])[O:16][CH2:17][c:18]3[cH:19][cH:20][cH:21][cH:22][cH:23]3)[CH2:12][CH2:13]2)[cH:6][cH:7]1)[CH2:52][CH2:51][CH2:50][NH:49][c:43]1[c:42]([F:41])[cH:47][cH:46][c:45]([F:48])[cH:44]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-cec868e7bbb84fc8aae8691b9d7e9ea4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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