Potassium Carbonate → 4-(4-Fluorobenzyl)-1-(2-(2-hydroxynaphth-6-oxy)ethyl)piperidine

HRID 1955246Notes

Reaction equation

HRID 1955246 reaction equation
[F:1][C:2]1[CH:14]=[CH:13][C:5]([CH2:6][CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[CH2:15]([O:22][C:23]1[CH:32]=[CH:31][C:30]2[C:25](=[CH:26][CH:27]=[C:28]([O:33]CCBr)[CH:29]=2)[CH:24]=1)[C:16]1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH:7]2[CH2:8][CH2:9][N:10]([CH2:16][CH2:15][O:22][C:23]3[CH:24]=[C:25]4[C:30](=[CH:31][CH:32]=3)[CH:29]=[C:28]([OH:33])[CH:27]=[CH:26]4)[CH2:11][CH2:12]2)=[CH:13][CH:14]=1

Participants

4

Reactant 3

HCID 11430Potassium CarbonateHCID 36998414-(4-Fluoro-benzyl)-piperidineHCID 232943452-Benzyloxy-6-(2-bromo-ethoxy)-naphthalene

Product 1

HCID 232942364-(4-Fluorobenzyl)-1-(2-(2-hydroxynaphth-6-oxy)ethyl)piperidine

Procedure

The title compound was prepared from 4-(4-Fluoro-benzyl)-piperidine and 2-benzyloxy-6-(2-bromo-ethoxy)-naphthalene and potassium carbonate in two steps as a solid, mp184-185° C. Analysis calculated for C24H26FNO2 : C, 75.96; H, 6.91; N, 3.69; F, 5.01. Found: C, 75.52; H, 6.86; N, 3.50; F, 5.15.

Sources & evidence

ORD record
ord-b630f12d570c43a08150f70f7ea58602
Source dataset
uspto-grants-2000_09
Patent number
US06124323

Reaction notes

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