Hydrochloric Acid → HCID 9799901, compound

HRID 1955342Notes

Reaction equation

HRID 1955342 reaction equation
[ClH:1].C(C1C=CC(OCCCN2CC3CCC2CC3)=CC=1)#C.[CH:22]12[CH2:29][CH2:28][CH:25]([CH2:26][CH2:27]1)[CH2:24][N:23]2[CH2:30][CH2:31][CH2:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]#[C:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])=[CH:36][CH:35]=1.Cl>C(OCC)C>[CH:22]12[CH2:29][CH2:28][CH:25]([CH2:26][CH2:27]1)[CH2:24][N:23]2[CH2:30][CH2:31][CH2:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]#[C:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])=[CH:36][CH:35]=1.[ClH:1].[CH:22]12[CH2:29][CH2:28][CH:25]([CH2:26][CH2:27]1)[CH2:24][N:23]2[CH2:30][CH2:31][CH2:32][O:33][C:34]1[CH:39]=[CH:38][C:37]([C:40]#[C:41][C:42]([O:44][CH2:45][CH3:46])=[O:43])=[CH:36][CH:35]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 9799902HCID 9799902, compoundHCID 9861328HCID 9861328, compound

Product 2

HCID 9799901HCID 9799901, compoundHCID 9799902HCID 9799902, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Ethyl 4-[3-(2-azabicyclo[2.2 2]octan-2-yl)propoxy]phenylpropiolate (compound 11) was prepared from compound 10 according to the method of example 2, then compound 11 was treated with HCl in ethyl ether in accordance with the method of example 1 (c). Ethyl 4-[3-(2-azabicyclo[2.2.2]octan-2-yl) propoxy]phenylpropiolate hydrochloride (compound 12) was obtained as a pale yellow crystal. The physical data is shown as follows.

Sources & evidence

ORD record
ord-5ebe737c00214fa987b162ee97c80916
Source dataset
uspto-grants-2000_09
Patent number
US06124460

Reaction notes

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