1,1'-Carbonyldiimidazole → HCID 19071300, compound

HRID 1955628Notes

Reaction equation

Cl.[CH:2]1([CH2:9][NH2:10])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.[C:11]([N:18]1[CH:22]=[CH:21]N=C1)(N1C=CN=C1)=[O:12]>>[CH:2]1([CH2:9][NH:10][C:11]([NH:18][CH2:22][CH:21]2[CH2:5][CH2:4][CH2:3][CH2:2][CH2:8][CH2:7]2)=[O:12])[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

Reactant 2

HCID 682631,1'-Carbonyldiimidazole

HCID 19071321Cycloheptylmethylamine

Product 1

HCID 19071300HCID 19071300, compoundYield 24%

Procedure

In the manner of step (a) of Example 6, cycloheptanemethylamine hydrochloride (R. B. Turner and R. H. Garner, J. Amer. Chem. Soc. 1958, 80:1424-1430; 22.00 g, 0.135 mole) was reacted with 1,1'-carbonyldiimidazole to give 1,3-bis(cycloheptylmethyl)urea as a white powder (4.45 g, 24%), m.p. 106°-108° C.; 1H-NMR (DMSO-d6) consistent with structure.

Sources & evidence

ORD record: ord-a84ebbf1e3b74be286b5f14623a0538a
Source dataset: uspto-grants-1998_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05776940

Reaction notes

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