反应详情

Benzylchloroformate (0.35 ml; 2.3 mmol) was added to a mixture of L-allothreonine (0.25 g; 2.1 mmol) and NaHCO3 (435 mg; 5.18 mmol) in 2.5 ml of H2O at RT. After 3 h, the reaction mixture was partitioned between Et2O and H2O. The aqueous layer was washed with Et2O, acidified to pH<2 with 6N HCl, and extracted with CH2Cl2. The organic layer was dried (MgSO4) and concentrated to afford 320 mg (63%) of Cbz-L-allothreonine. ##STR398##

1. customthe reaction mixture was partitioned between Et2O and H2O
2. washThe aqueous layer was washed with Et2O
3. extractionextracted with CH2Cl2
4. dry with materialThe organic layer was dried (MgSO4)
5. concentrationconcentrated