Hydrochloric Acid → Methyl 2-(4-(bromomethyl)phenyl)acetate

HRID 1955729Notes

Reaction equation

HRID 1955729 reaction equation
[Br:1][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.Cl.[CH3:14]OC(OC)(C)C>>[Br:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:9][C:10]([O:12][CH3:14])=[O:11])=[CH:7][CH:8]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 64952,2-DimethoxypropaneHCID 45190564-(Bromomethyl)phenylacetic acid

Product 1

HCID 11770640Methyl 2-(4-(bromomethyl)phenyl)acetate

Procedure

5 g (22 mmol) of 2-(4-bromomethyl-phenyl)-acetic acid are stirred at room temperature overnight in 50 ml of 2,2-dimethoxypropane with addition of 2 ml of aqueous conc. hydrochloric acid. After concentration, methanol is added twice in each case, the mixture is concentrated again and the residue is then dried in vacuo.

Workup

  1. concentrationAfter concentration, methanol
  2. additionis added twice in each case
  3. concentrationthe mixture is concentrated again
  4. customthe residue is then dried in vacuo

Sources & evidence

ORD record
ord-46add129d6f447c3a4c0e4a9f7a24b82
Source dataset
uspto-grants-1998_07
Patent number
US05776964

Reaction notes

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