反应详情

To a solution of N-(2',5'-bistrifluoromethylphenyl)-4-oxa-androst-5-en-3-one-17β-carboxamide (230 mg, 0.433 mml, prepared according to the procedures of Example 7) in THF (5 mL) was added 5% Rh/C (200 mg). After stirring the reaction mixture for overnight under hydrogen atmosphere, the reaction mixture was flushed with nitrogen, filtered, concentrated and purified by preparative tlc (50% EtOAc/hexane) to give pure product. Mass spec. M+ 532 (m+1, observed).

1. customthe reaction mixture was flushed with nitrogen
2. filtrationfiltered
3. concentrationconcentrated
4. custompurified by preparative tlc (50% EtOAc/hexane)
5. customto give pure product