6-Methoxy-1-Indanone → HCID 9862887, compound

HRID 1956156Notes

Reaction equation

HRID 1956156 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[C:10]2[C:6]([CH2:7][CH2:8][C:9]2=O)=[CH:5][CH:4]=1.[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[C:18]([N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1)=[O:19].[BH4-].[Na+]>CC(C)[O-].[Ti+4].CC(C)[O-].CC(C)[O-].CC(C)[O-]>[S:13]1[CH:17]=[CH:16][CH:15]=[C:14]1[C:18]([N:20]1[CH2:21][CH2:22][N:23]([CH:9]2[C:10]3[C:6](=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[CH:11]=3)[CH2:7][CH2:8]2)[CH2:24][CH2:25]1)=[O:19]

Participants

5

Reactant 3

HCID 3340366-Methoxy-1-IndanoneHCID 7975621-(Thien-2-ylcarbonyl)piperazineHCID 4311764Sodium borohydride

Product 1

HCID 9862887HCID 9862887, compound

Reagents, catalysts & solvents 1

HCID 11026Titanium isopropoxideCatalyst

Procedure

The title compound was prepared by the above procedure using 6-methoxy-1-indanone (2.6 g, 13.2 mmol), 1-(2-thienylcarbonyl)piperazine (2.1 g, 13.2 mol), titanium(IV) isopropoxide (5 mL, 15 mmol) and sodium borohydride (2.7 g, 67 mmol) to give 1.5 g of product as the fumarate salt.

Sources & evidence

ORD record
ord-0233c621d70c4fd5af7f691f07d0ad2d
Source dataset
uspto-grants-1998_07
Patent number
US05780470

Reaction notes

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