1-(2-Methoxyphenyl)piperazine → HCID 18663119, compound

HRID 1956245Notes

Reaction equation

HRID 1956245 reaction equation
[CH2:1]([C:3]1[CH:4]=[C:5]([NH:12][C:13](=[O:16])[CH2:14]Cl)[C:6]([O:10][CH3:11])=[N:7][C:8]=1[CH3:9])[CH3:2].[CH3:17][O:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1.C1CCN2C(=NCCC2)CC1>O1CCCC1>[CH2:1]([C:3]1[CH:4]=[C:5]([NH:12][C:13]([CH2:14][N:28]2[CH2:27][CH2:26][N:25]([C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=3[O:18][CH3:17])[CH2:30][CH2:29]2)=[O:16])[C:6]([O:10][CH3:11])=[N:7][C:8]=1[CH3:9])[CH3:2]

Participants

5

Reactant 3

HCID 13461-(2-Methoxyphenyl)piperazineHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 18663159HCID 18663159, compound

Product 1

HCID 18663119HCID 18663119, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

After N-(5-ethyl-2-methoxy-6-metylpyridine-3-yl)chloroacetamide(0.10 g, 0.43 mmol) and 1-(2-methoxyphenyl)piperazine(0.0091 g, 0.47 mmol) were dissolved into tetrahydrofuran(5 ml) and was added DBU(0.060 g, 0.43 mmol), the reaction mixtures were stirred at room temperature for 2 hours. After the product of reaction were concentrated, separated by column chromatography to obtain 0.12 g of the titled compound.

Workup

  1. customthe reaction mixtures
  2. customAfter the product of reaction
  3. concentrationwere concentrated
  4. customseparated by column chromatography

Sources & evidence

ORD record
ord-35a54000756743b4a072448d1639d39a
Source dataset
uspto-grants-1998_07
Patent number
US05780472

Reaction notes

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