Phosphorus oxychloride → HCID 23209276, compound

HRID 1956418Notes

Reaction equation

HRID 1956418 reaction equation
[CH2:1]([C:3]1[N:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[CH:8][C:7]([C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:6]2O)[CH3:2].P(Cl)(Cl)([Cl:21])=O>>[Cl:21][C:6]1[C:5]2[C:10](=[CH:11][CH:12]=[C:3]([CH2:1][CH3:2])[N:4]=2)[N:9]=[CH:8][C:7]=1[C:13]([O:15][CH2:16][CH3:17])=[O:14]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 178469536HCID 178469536, compound

Product 1

HCID 23209276HCID 23209276, compound

Procedure

A mixture of ethyl 6-ethyl-4-hydroxy-1,5-naphthyridine-3-carboxylate (3.0 g) and phosphorus oxychloride (25 ml) was stirred and heated at 40°-50° C. for 1 hour. The mixture was then cooled and then worked up as described in Example B1 to give ethyl 4-chloro-6-ethyl-1,5-naphthyridine-3-carboxylate, m.p. 94°-96° C.

Workup

  1. temperatureheated at 40°-50° C. for 1 hour
  2. temperatureThe mixture was then cooled

Sources & evidence

ORD record
ord-87ceb326d7d448498b7332ab8dea9228
Source dataset
uspto-grants-1998_07
Patent number
US05780482

Reaction notes

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